In the 80s and 90s, scientists discovered the phenomenon of genetic chronometers, a kind of tools for calibrating the vital functions of a cell depending on the time of day. This phenomenon was called circadian rhythms, and after decades of research on them, the 2017 Nobel Prize in Physiology or Medicine was awarded. Today, this knowledge has been transformed into practical advice and methods that may sound very simple, but are critical for the health and life of people.
The activation of a huge number of functions in the body, the work of about half of the entire genome, depends on the diagrams of circadian rhythms. Disruptions in rhythms lead to the fact that cells, entire organs and even systems begin to work "inappropriately". And this is already becoming the cause of almost all internal ailments and disorders that one can imagine. The gene clock does not last forever, it necessarily begins to malfunction as we age, but the process can spur a ragged circadian rhythm, mutations and stress.
Even worse, the effectiveness of drug use depends on the genetic clock - if you do not hit the right "window", the active substance may not reach the desired organ, the transportation system will carry it by. The function that was going to be affected may be disabled and the effect will not work. Or the body will simply reject the drug, if you do not guess with the timing of its intake. The science of chronobiology is dealing with these issues, and it already has results: with chemotherapy, sessions are selected taking into account the peak activity of individual genes, which increases the patient's survival.
Tips for normalizing the genetic clock are very simple and familiar to everyone, only now they have a serious scientific basis for them. For example, a healthy and regular sleep, plus walking in the fresh air can "restart" this mechanism. If you are vaccinated against the flu in the morning, the production of antibodies to the pathogen increases by 4 times. But heart surgery is best done in the afternoon - the risk of an attack is halved. It is necessary to sleep at night, and not work in the third shift, and eat all the food within 10 hours of one day, without "going to the refrigerator" in the middle of the night.
The gene clock is easily lost, but it is relatively easy to restart it, for which sometimes it is enough to change the environment and daily routine for a short time, spontaneously getting out on a mini-vacation.