There are two types of fat in the human body - conditionally healthy "brown" and harmful "white", which so easily accumulates on the stomach and thighs. Purdue University has developed a drug to convert one type of fat into another, and to achieve the best effect, they want to inject the drug pointwise, in the form of injections from nanoparticles. Several sessions of injections - and the body itself will begin to fight obesity.
The mechanism of conversion of white fat to brown is based on blocking the signaling system that exists between the cells of adipose tissue. Fat cells are able to influence the genes of neighbors and turn them into their own kind, with white fat clearly dominating over brown. But if you block this connection, its spread will stop. And instead of deposits of useless fat in the body, the reserves of energy substances we need will accumulate.
The blockage of intercellular connections is caused by the drug Dibenzazepine, which scientists propose to pack in tiny capsules with a diameter of 200 nanometers with a polymer shell. It dissolves rather slowly, so all the substance will be absorbed only by nearby cells and will not spread throughout the body. Instead of taking pills and mixtures, one injection is made into the target area - over time, the white fat in it will be replaced by brown on its own.
Experiments on well-fed mice have shown that the idea is more than workable, and in addition to reducing the amount of fat in animals, the risk of diabetes and other diseases associated with obesity decreases. The plans for the use of nanoparticle injections in humans have not yet been announced, but the technology is workable and is by no means a fantasy.
The details of this study were published in the journal Molecular Therapy.