Adenosine Bioligation Effectively Heals Broken Bones

Scientists from Duke University in North Carolina (USA) have developed a technology for the controlled concentration of adenosine at the sites of bone damage. This will influence the rate and quality of bone tissue fusion. The idea is based on the principle of a bandage - a special bio-bandage with active substances is surgically applied directly to the bone.

The problem of bone fusion after fractures is that adenosine acts as the main working substance in this process, which also has a wide range of other functions. This is one of the fundamental substances in demand in different parts of the body. In response to injury, the body begins to release large, even excessive amounts of adenosine, but as soon as the process of bone healing starts, the flow dries up. Because of this, in natural conditions, bones grow together as necessary, but scientists want to control this process.

The idea lies on the surface - if there is enough adenosine, you just need to keep it in the wound area for as long as possible. For this, it was decided to apply a dressing with boronate molecules, which easily forms bonds with adenosine. But they are not eternal, and as the bonds weaken, adenosine will be released back, participating in the healing process. And the dressing itself will eventually disintegrate into neutral compounds.

In experiments on experimental mice, the best results were obtained where dressings with a high concentration of boronate and a bandage previously saturated with adenosine were used. Within three weeks, the broken bones were completely restored. However, the process has some side effects, so research will continue.