Biomedical engineers from Tel Aviv University (Israel) have developed a new effective weapon to fight cancer. They have learned to destroy them with local explosions, using microscopic gas bubbles for this. And to enhance the effect, they added an additional damaging element to this bioexplosive - the immunotherapy gene.
Initially, Israeli researchers studied the effect of ultrasound on cancers, but then turned their attention to the behavior of microbubbles. When they were irradiated at high frequencies, the bubbles were compressed, and at low frequencies, they expanded. By choosing the right frequencies, scientists achieved an explosive expansion effect, which became a tool for fighting cancer cells.
Gas microbubbles are injected directly into the tumor, then an ultrasound emitter at a frequency of 250 kHz is turned on and a microexplosion occurs. Exploding bubbles destroy up to 80% of the tumor, and an immunotherapy gene is used to eliminate the remaining cells. It causes cells to produce a signaling substance that attracts phagocytes and "highlights" targets for them.
The explosion destroys the center of the tumor, punches holes in its membrane and opens up ways for the immune system to attack, which finishes the remaining cells. The technology has been successfully tested on a breast cancer model and has shown excellent results. Now there is a check - is it possible with its help to temporarily break through the blood-brain barrier, which interferes with the delivery of drugs to the target organs.